Preeclampsia is one of the major causes of maternal and perinatal death, mainly in the severe early-onset presentation. Second trimester uterine artery Doppler has been demonstrated to be the most sensitive isolated predictive marker of early-onset preeclampsia. However, consistent evidence demonstrated that preventive therapies (aspirin or antioxidants) are not useful during mid-gestation. First trimester uterine artery Doppler has lower sensitivities for severe preeclampsia than second trimester measurement, but by performing a combined predictive model (uterine artery Doppler, biochemical angiogenic markers such as Placental Growth Factor, mean arterial blood pressure and maternal history) the sensitivity is significantly improved. Moreover, recent meta-analysis demonstrated that preventive therapies such as aspirin are useful only when begins before 16 weeks. The Nerve Growth Factor (NGF) is a member of the neurotrophin family with an important role in the development of cholinergic neurons. Recent studies demonstrated that NGF is a potent angiogenic factor in non-neurologic tissues. Patients with preeclampsia demonstrated decreased plasma levels of NGF immediately before delivery. The aim of this review is to evaluate the potential role of NGF as a biochemical
marker of altered angiogenesis during pregnancy for prediction of early-onset preeclampsia
Palabras clave:
Factor de Crecimiento Nervioso, Embarazo, Preeclampsia
Sepúlveda-Martínez, Álvaro ., Romero O., C. ., Vega I., M. ., & Parra-Cordero, M. . (2014). ¿Es el factor de crecimiento nervioso (NGF) un marcador útil durante el embarazo para la predicción de preeclampsia precoz?. Revista Hospital Clínico Universidad De Chile, 25(2), pp. 135–42. https://doi.org/10.5354/2735-7996.2014.72891
