Péptidos inmunogénicos del gluten en deposiciones. Nuevo método para evaluar la adherencia a la dieta en pacientes celíacos

Autores/as

  • Julio Miranda B. Hospital Clínico Universidad de Chile. Departamento de Medicina. Sección de Gastroenterología. Laboratorio de Gastroenterología
  • Natalia Covarrubias R. Hospital Clínico Universidad de Chile. Departamento de Medicina. Sección de Gastroenterología. Laboratorio de Gastroenterología
  • Gonzalo Araneda M. Hospital Clínico Universidad de Chile. Departamento de Medicina. Sección de Gastroenterología
  • Carmen Hurtado H. Hospital Clínico Universidad de Chile. Departamento de Medicina. Sección de Gastroenterología. Laboratorio de Gastroenterología
  • Claudia Defilippi G. Hospital Clínico Universidad de Chile. Departamento de Medicina. Sección de Gastroenterología.

Resumen

Celiac disease (CD) is an autoimmune pathology caused by the ingestion of gluten in genetically susceptible people, currently considered multisystemic. The treatment of CD is a lifelong strict Gluten-Free Diet (GFD), which allows a symptomatic improvement in most patients and achieve intestinal mucosa healing confirmed with histological study. The adherence to the GFD is variable, arguing as possible factors related to failure the economic, cultural, social aspects and the consumption of gluten inadvertently. The management of celiac patients contemplates instructing in the proper follow-up of GFD and evaluating their adherence. So far, the only way to assess adherence to GFD is through surveys, self-reports of eating habits and serology, being the main disadvantage the subjectivity factor. Recently the immunogenic gluten peptides have acquired relevance for the objective evaluation of the adherence to the GFD and the measurement appears as an efficient and sensitive option to determine the gluten intake, providing relevant information for the clinical management.

Palabras clave:

Enfermedad Celíaca, Glútenes, Péptidos