Obesidad, inflamación y glucocorticoides

Autores/as

  • Karin Papapietro V. Hospital Clínico Universidad de Chile. Departamento de Cirugía
  • Julia Guerrero P. Universidad de Chile

Resumen

Obesity is a worldwide problem that also involves our country. It reduces life expectancy and represents a high economic burden for individual and the society. A large amount of economic and human resources has been allocated for obesity control and prevention. Obesity is associated with the main non-transmissible diseases on this time: cardiovascular diseases, type 2 diabetes mellitus, arterial hypertension, osteoarticular disease and some types of cancer. The development of obesity include genetic, environmental and lifestyle factors. While lipid accumulates into the adipocyte, it becomes in a tissue with hypertrophy and hyperplasia and inflammatory cells infiltrate it. Although it is not known the primary stimulus that triggers this inflammatory phenomenon, it is known this has deleterious consequences in the local and systemic metabolism and give the obese phenotype with insulin resistance, atherogenesis and inflammation. Glucocorticoids are steroidal hormones with multiple actions such as anti- inflammatory properties. In obese patients, even when the plasma level of cortisol may be normal, glucocorticoids are unable to achieve regulation of the pro-inflammatory state that characterizes it. Bariatric surgery, along with recovering the weight, has been found to resolve systemic inflammatory status. The relationship between bariatric surgery, weight recovery and glucocorticoid activity has not been studied yet.

Palabras clave:

Obesidad, Glucocorticoide, Inflamación